Coco B Isla, Isla Mujeres There’s nothing else like this high-design luxury boutique hotel collection in the heart of beautiful Isla Mujeres, Mexico. Equal parts hotel and villa collection, it’s the best of both worlds, with the privacy and comfort you look for in villa accommodations with the terrific service of a boutique hotel. Even better? The hotel’s location means it has no issues with sargassum, a significant problem in much of the Mexican Caribbean of late.