Casas del XVI, Dominican Republic The five-hundred-year-old Colonial Zone of Santo Domingo is just starting to get its spot in the limelight, but in-the-know travelers have long fallen in love with its historic charm. And Casas del XVI, with rooms scattered across a collection of six gorgeously restored homes all dating to the 16th century, is the quarter’s luxury leader, with jaw-dropping design that is unique to each home.